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Showing 1 to 12 of 30 entries
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Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines.

Journal of translational science

Ishiguro K, Zhu YL, Lin ZP, Penketh PG, Shyam K, Zhu R, Baumann RP, Sartorelli AC, Rutherford TJ, Ratner ES.
PMID: 27076919
J Transl Sci. 2016;2(2):117-124. doi: 10.15761/JTS.1000127. Epub 2016 Mar 05.

Although epithelial ovarian cancers (EOCs) are initially treated with platinum-based chemotherapy, EOCs vary in platinum responsiveness. Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive EOC cell lines is valuable for development of therapeutic strategies to avoid...

Inaugural Message from the Founding Editor-in-Chief.

Journal of translational science

Maiese K.
PMID: 26161264
J Transl Sci. 2015 May 28;1(1):1. doi: 10.15761/JTS.1000101.

No abstract available.

Hemostasis, bleeding and thrombosis in liver disease.

Journal of translational science

Flores B, Trivedi HD, Robson SC, Bonder A.
PMID: 30221012
J Transl Sci. 2017 May;3(3). doi: 10.15761/JTS.1000182. Epub 2017 Mar 04.

The presence of cirrhosis poses an increased risk of both thrombosis and bleeding in individuals with chronic liver disease. This duality is a result of a dynamic disequilibrium between procoagulant and anticoagulant states in individuals with cirrhosis. The mechanism...

First-in-human phase 0 study of .

Journal of translational science

Kurdziel KA, Mena E, McKinney Y, Wong K, Adler S, Sissung T, Lee J, Lipkowitz S, Lindenberg L, Turkbey B, Kummar S, Milenic DE, Doroshow JH, Figg WD, Merino MJ, Paik CH, Brechbiel MW, Choyke PL.
PMID: 30906574
J Transl Sci. 2019 Apr;5(2). doi: 10.15761/JTS.1000269. Epub 2018 Jul 13.

No abstract available.

The roles of homologous recombination and the immune system in the genomic evolution of cancer.

Journal of translational science

Nandi B, Talluri S, Kumar S, Yenumula C, Gold JS, Prabhala R, Munshi NC, Shammas MA.
PMID: 30873294
J Transl Sci. 2019 Apr;5(2). doi: 10.15761/JTS.1000282. Epub 2018 Oct 01.

A variety of factors, whether extracellular (mutagens/carcinogens and viruses in the environment, chronic inflammation and radiation associated with the environment and/or electronic devices/machines) and/or intracellular (oxidative metabolites of food, oxidative stress due to inflammation, acid production, replication stress, DNA...

A comparison of genetic sampling methodologies for candidate-gene analyses.

Journal of translational science

Sun J, Tung SR, Wang D, Kitzmiller JP, Smith S.
PMID: 31749990
J Transl Sci. 2019 Jun;5(3). doi: 10.15761/JTS.1000306. Epub 2018 Aug 25.

Much of the recent gains in knowledge regarding the influence of patient genetics on medication pharmacokinetics (drug absorption, distribution, metabolism and elimination) how patients process medications) and pharmacodynamics (drug response) have been attributed to the technologic advances in genetic...

The geropathology of organ-specific aging.

Journal of translational science

Klug J, Christensen S, Imai DM, Snider TA, Ladiges W.
PMID: 34504718
J Transl Sci. 2021 Feb;7(1). doi: 10.15761/jts.1000458. Epub 2021 Jun 16.

Aging is a complex multidimensional process of progressive decline affecting multiple organ systems by a number of processes that are still not well understood. While many studies have focused on the approach of studying aging across multiple organs, assessment...

Pharmacological approaches to the treatment of COVID-19 patients.

Journal of translational science

Sowers LC, Blanton LS, Weaver SC, Urban RJ, Mouton CP.
PMID: 33042589
J Transl Sci. 2020 Dec;6(6). Epub 2020 Apr 17.

The current COVID-19 pandemic has presented unprecedented challenges to the world community. No effective therapies or vaccines have yet been established. Upon the basis of homologies to similar coronaviruses, several potential drug targets have been identified and are the...

Neuronal Activity, Mitogens, and mTOR: Overcoming the Hurdles for the Treatment of Glioblastoma Multiforme.

Journal of translational science

Maiese K.
PMID: 26120474
J Transl Sci. 2015;1(1):2.

Glioblastoma multiforme (GBM) and other malignant gliomas are considered to be the most prevalent of primary malignant brain tumors. The incidence of these tumors per year is reported as 4.13 per 100,000 individuals per year. The median survival time...

MicroRNAs and SIRT1: A Strategy for Stem Cell Renewal and Clinical Development?.

Journal of translational science

Maiese K.
PMID: 26561536
J Transl Sci. 2015 Nov;1(3):55-57. Epub 2015 Oct 08.

Small non-coding ribonucleic acids (RNAs), known as microRNAs (miRNAs), are now becoming recognized as significant agents that can affect the onset and progression of numerous disorders throughout the body. In particular, miRNAs also may determine stem cell renewal and...

Serum levels of gamma-glutamyl transpeptidase in relation to HCC human biology and prognosis.

Journal of translational science

Carr BI, Akkiz H, Bag HG, Karaoğullarından U, Yalçın K, Ekin N, Özakyol A, Altıntaş E, Balaban HY, Şimşek H, Uyanıkoğlu A, Balkan A, Kuran S, Üsküdar O, Ülger Y, Güney B, Delik A.
PMID: 34540270
J Transl Sci. 2021 Jun;7(3). doi: 10.15761/jts.1000446. Epub 2020 Sep 17.

BACKGROUND AND AIM: Hepatocellular carcinoma (HCC) biomarkers are limited, as even the best studied, alpha-fetoprotein (AFP), is elevated in no more than 50% of HCC patients. The aim was to evaluate several serum liver function tests in relation to...

Charting a course for erythropoietin in traumatic brain injury.

Journal of translational science

Maiese K.
PMID: 27081573
J Transl Sci. 2016 Mar;2(2):140-144. doi: 10.15761/jts.1000131. Epub 2016 Mar 26.

Traumatic brain injury (TBI) is a severe public health problem that impacts more than four million individuals in the United States alone and is increasing in incidence on a global scale. Importantly, TBI can result in acute as well...

Showing 1 to 12 of 30 entries